Felix Otton, from Heriot, a member of local running club Gala Harriers, was first to complete the five kilometre course, which started and finished at St Mary's School, in a time of 20 minutes and seven seconds.
The first lady home was Fiona Miller, from Selkirk, in a time of 26 minutes and three seconds.
And Lesley Anne Renwick, Kirsty Meldrum, and Leanne Walker, all of Merlin Veterinary Group in Galashiels, won the prize for best fancy dress on completion of the course. They thanked their colleague Lynn Allan for creating their crowns and t-shirts for the Royal party.
Other runners included school headmaster Liam Harvey, television news presenter Cameron Buttle, Border Telegraph reporter Ally McGilvray and Michael Crawford, who organised the event on Sunday to raise cash for the Borders branch of the Multiple Sclerosis Society.
However, everyone who finished, whether walking or running the route, was presented with a specially produced medal, presented by Melrosian Graeme Crawford, to commemorate the occasion.
Reflecting on the day, Michael said: "It's been a really good day and the weather's been kind. And everyone I passed, which wasn't that many, seemed to enjoy it. Originally, when we started this event, it was meant to be a one-off but we have had such positive feedback we have kept on going."
Refreshments and a barbecue were enjoyed by all at the conclusion. In addition the towns shops and hotels joined in with red, white and blue bunting and merchandise in virtually every window and the ever industious Melrose in Bloom Committee giving visitors to the town a floral treat for the occasion.
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