The incident happened sometime between 1pm on Saturday 9th February and 4.15pm on Friday 15th February at an address in Main Street, Gavinton, Duns.
A family member of the homeowners visited the property and discovered that entry had been gained and various items of expensive jewellery had been taken from inside.
The estimated value of the stolen goods is believed to be around £50,000.
Officers are now urging anyone who can assist with their enquiries to contact police immediately.
Detective Constable Keith Brydon said: "The property owners have been left devastated by the theft of their jewellery and are keen to have the items returned as soon as possible.
"We would like to hear from anyone who remembers seeing anything suspicious in the Main Street area of Gavinton between the 9th and 15th February and are particularly keen to speak to those who remember seeing a white Transit van, which was seen outside the address on Friday afternoon.
"Similarly, anyone with any other information that can assist with our investigation is also asked to come forward."
Those with information can contact Lothian and Borders Police on 0131 311 3131, or the charity Crimestoppers in complete anonymity on 0800 555 111.